STE7 — Saccharomyces cerevisiae S288c

Summary

YDL159W encodes a protein with MAPKK activity, protein tyrosine kinase activity, protein kinase activity, protein serine kinase activity, and protein serine/threonine kinase activity, and is associated with ERK1. This gene is associated with the MAPK cascade, pheromone response, pseudohyphal growth, retrotransposition, regulation of ascospore formation, and other biological processes. It localizes to the cytoplasm, cytosol, nucleus, cell tip, division septum, and other sites. Phenotypic associations include absent mating response and shmoo formation, decreased invasive growth, increased killer toxin resistance, and decreased replicative lifespan. Related genes in other species link the family to mitogen-activated protein kinase kinase activity (EC 2.7.12.2) and, in some cases, loss of pathogenicity.