NSI1 — Saccharomyces cerevisiae S288c

Summary

YDR026C (REB1) in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with RNA polymerase II-specific activator activity and sequence-specific DNA binding, including binding to the RTS1 replication fork barrier and transcription termination sites. It is associated with site-specific DNA replication termination at the RTS1 barrier, replication fork arrest in rDNA repeats, RNA polymerase I transcription termination, and cell cycle processes. The gene product localises to the nucleus, rDNA heterochromatin, and the NuR complex. Phenotypic associations include decreased replicative lifespan, decreased vegetative growth rate, abnormal vacuolar morphology, decreased competitive fitness, and altered chemical resistance. Studies of related genes in other species link the family to reduced virulence.