SSS1 — Saccharomyces cerevisiae S288c

Summary

YDR086C (SSS1) in Saccharomyces cerevisiae S288c on chromosome IV encodes a component of the Sec61 and Ssh1 translocon complexes, possessing protein transmembrane transporter activity. The gene is associated with posttranslational and SRP-dependent cotranslational protein membrane targeting, translocation, and protein-ER insertion, as well as vesicle tethering, translation, ER stress response, cell wall biogenesis, protein secretion, exocytosis, intracellular protein transport, vacuolar protein sorting, lipid metabolism, mitochondrial genome maintenance, double-strand break repair, glycosylation, and RNA processing. It localises to the ER membrane and translocon complexes. Phenotypic associations include abnormal ER morphology, increased innate thermotolerance, increased protein/peptide accumulation, inviability, decreased vegetative growth, increased heat sensitivity, haploinsufficiency, and altered chemical resistance. Studies of related genes in other species link the family to protein transport.