SUP35 — Saccharomyces cerevisiae S288c

Summary

YDR172W (SUP35) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with translation release factor activity, GTPase activity, GTP binding, and magnesium binding, and also possesses translation elongation factor activity. The protein is a TRAFAC GTPase family member and localises to the cytoplasm, cytosol, and translation release factor complex. SUP35 is associated with numerous biological processes including cytoplasmic translational termination, regulation of translational fidelity, translational readthrough, protein polymerization, amyloid fibril formation, and cellular thermotolerance. It has been linked to traits such as seed size, amino acid content, and oxidative stress, as well as phenotypes including altered prion formation and loss, increased budding index, abnormal nucleolar morphology, decreased vegetative growth, increased heat sensitivity, and decreased chemical resistance. Studies of related genes in other species connect the family to GTPase activity (EC 3.6.5.-).