ADR1 — Saccharomyces cerevisiae S288c

Summary

YDR216W in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription activator with RNA polymerase II-specific activity, containing a C2H2-type zinc finger domain. It is associated with diverse biological processes including RNA surveillance, nonsense-mediated mRNA decay, response to water and methanol, regulation of gluconeogenesis, cell wall thickening, siderophore anabolism, fatty acid oxidation, and cellular response to calcium ions. The gene is linked to traits such as glucose content, oxidative stress, light sensitivity, and acid sensitivity. Phenotypic associations include increased lifespan, stress resistance, invasive growth, and competitive fitness, as well as decreased UV and hyperosmotic stress resistance. Localization evidence connects the product to heterochromatin, chromatin, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence.