MSN5 — Saccharomyces cerevisiae S288c

Summary

YDR335W, also known as MSN5, is located on chromosome IV of Saccharomyces cerevisiae S288c. It encodes a nuclear export signal (NES) receptor with nuclear import signal receptor activity, GTP binding, and RNA binding capabilities. The gene product is associated with a wide range of biological processes including nuclear transport, tRNA charging and nuclear import, iron-sulfur cluster assembly, pheromone response, sphingolipid anabolism, translation elongation, cell cycle modulation, and glycosylation. It localizes to the RNA nuclear export complex, nuclear envelope, cytoplasm, cytosol, and nucleus. MSN5 is linked to numerous traits and phenotypes, including acid sensitivity, iron concentration, light sensitivity, oxidative stress, decreased mating response, abnormal RNA localization, increased cell size, decreased replicative and chronological lifespan, increased stress resistance, decreased desiccation and toxin resistance, and decreased vegetative growth rate.