GCN4 — Saccharomyces cerevisiae S288c

Summary

YEL009C (GCN4) on Saccharomyces cerevisiae chromosome V encodes a DNA-binding transcription factor that acts at RNA polymerase II cis-regulatory regions, belonging to the bZIP and AP-1 transcription factor families. The gene is associated with downregulation of glycolysis, triglyceride metabolism, membrane lipid anabolism, cargo selection, response to cadmium, nucleotide anabolism, late endosome-to-vacuole transport, capsid maturation, amino acid import, memory, vesicle fusion, response to UV-B, response to amino acid, glycerol anabolism, regulation of translation, seed abscission, immune memory response, and DNA transport. The encoded protein localises to the nucleus and transcription regulator complexes. Phenotypic associations include decreased osmotic stress resistance, acquired thermotolerance, pseudohyphal growth, autophagy, biofilm formation, UV resistance, and oxidative stress resistance, alongside increased viability, filamentous growth, chemical compound excretion, and replicative lifespan.