YEN1 — Saccharomyces cerevisiae S288c

Summary

YER041W, also known as YEN1, is a gene on chromosome V of Saccharomyces cerevisiae S288c that encodes a protein belonging to the XPG/Rad2 nuclease family, containing GEN1_C, Yen1_H3TH, and 5-3_exonuclease_C_sf domains. The encoded product is associated with multiple DNA repair pathways, including base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and double-strand break repair, as well as the resolution of meiotic recombination intermediates and sister chromatid segregation. The gene is linked to cell division, DNA replication, and the DNA damage response. Phenotypic associations include decreased resistance to heat, oxidative stress, desiccation, and starvation, along with altered competitive fitness and increased nucleolus size.