RSP5 — Saccharomyces cerevisiae S288c

Summary

YER125W (RSP5) in Saccharomyces cerevisiae S288c encodes an E3 ubiquitin-protein ligase with ubiquitin-protein transferase activity, ubiquitin and phospholipid binding, and a HECT domain. It is associated with protein ubiquitination, endosomal transport, amino acid import and transport, response to amino acids, protein refolding, tRNA and mRNA processing, RNA breakdown, cell polarization, vesicle formation, ethanol fermentation, pheromone response, and regulation of unsaturated fatty acid anabolism. The protein localizes to the RSP5-BUL1 complex, ubiquitin ligase complex, endosome membrane, Golgi complex, cell periphery, cellular bud tip, cytoplasm, and nucleus. The gene is linked to traits including amino acid and protein content, salt sensitivity, and oxidative stress, and to phenotypes such as decreased endocytosis, increased fermentative metabolism, decreased innate thermotolerance, decreased UV and oxidative stress resistance, increased heat sensitivity, and decreased vegetative growth.