SPT15 — Saccharomyces cerevisiae S288c

Summary

YER148W in Saccharomyces cerevisiae S288c encodes a protein with RNA polymerase II and III core promoter sequence-specific DNA binding activity, RNA polymerase III general initiation factor activity, and general RNA polymerase I transcription factor activity. It is a component of the TFIID, TFIIIB, and RNA polymerase I transcription regulator complexes and localizes to the nucleus. The gene is associated with transcription initiation from all three nuclear RNA polymerase promoters, as well as with DNA replication, homologous recombination, chromatin modeling, and DNA alkylation repair. It has been linked to isobutanol anabolism, ethanol fermentation, the TCA cycle, isoprenoid pathway, nucleotide metabolism, urea breakdown, proteasome degradation, and response to water. Associations with traits include oxidative stress, and phenotypes such as inviability, abnormal silencing and sporulation, altered vegetative growth, and changes in resistance to hyperosmotic stress, heat, toxins, and chemicals.