SEC4 — Saccharomyces cerevisiae S288c

Summary

YFL005W in Saccharomyces cerevisiae S288c encodes a small GTPase of the Rab family, possessing GTPase activity, GTP binding, and protein kinase regulator activity. This gene is associated with numerous cellular processes including exocytosis, secretion by cell, intracellular transport, cytokinesis, membrane fusion, SNARE complex assembly, spore formation, morphogenesis, and upregulation of TORC2 signaling. The encoded protein localizes to transport vesicle membranes, recycling endosomes, the endomembrane system, the cleavage furrow leading edge, and meiotic spindle pole bodies. YFL005W is associated with traits such as salt tolerance and oxidative stress. Phenotypic associations include decreased intracellular transport and protein secretion, abnormal chitin deposition and bud neck morphology, absent sporulation and protein secretion, increased cold and heat sensitivity, decreased oxidative stress resistance and vegetative growth, and inviability. Studies of related genes in other species, including SEC4 and ypt2, connect the Rab GTPase family to vesicle-mediated transport and polarized growth.