HAC1 — Saccharomyces cerevisiae S288c

Summary

YFL031W (HAC1) on chromosome VI of Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with RNA polymerase II-specific activity, belonging to the Hac1/HY5 and bZIP protein families. The gene is associated with the unfolded protein response, including ER stress response, response to misfolded protein, and ER-nuclear signaling pathway. It is linked to numerous cellular processes such as phospholipid metabolism, lipogenesis, exocytosis, mannosylation, and the pentose-phosphate shunt. HAC1 localizes to the nucleus and has been connected to traits including oxidative stress. Phenotypic associations include decreased replicative and chronological lifespan, reduced vegetative growth, abnormal cell cycle progression, altered ER morphology, and decreased stress resistance. Studies of related genes in other species link the family to virulence.