PHO4 — Saccharomyces cerevisiae S288c

Summary

YFR034C in Saccharomyces cerevisiae S288c encodes a basic helix-loop-helix (bHLH) domain-containing protein. This gene is associated with a wide range of biological processes, including polyphosphate and NAD metabolism, ribonucleotide breakdown, iron transport, calcium signaling, ethanol fermentation, and cell cycle modulation. It is also linked to responses to aluminum, trehalose, and oxidative stress. Phenotypic associations include decreased utilization of phosphorus and nitrogen sources, delayed G1 phase cell cycle progression, abnormal G2 phase progression, decreased alkaline pH resistance, decreased anaerobic and respiratory growth, decreased replicative lifespan, and altered competitive fitness. The gene is further connected to traits such as sodium, carbohydrate, and phosphate content, as well as calcium sensitivity. Related gene PHO4 is also associated with this gene.