OLE1 — Saccharomyces cerevisiae S288c

Summary

YGL055W (OLE1) on chromosome VII encodes a stearoyl-CoA 9-desaturase, an iron- and heme-binding enzyme. The gene product localises to the endoplasmic reticulum membrane, including perinuclear and cortical ER. OLE1 is associated with sterol homeostasis, lipid homeostasis, mitochondrial distribution and fusion, the ERAD pathway, very-long-chain fatty acid and acyl-CoA metabolism, regulation of unsaturated fatty acid anabolism, lycopene anabolism, pseudohyphal growth, fruiting body formation, RNA capping, and response to miconazole. Traits linked to OLE1 include oleic acid content, hydrogen peroxide content, germination rate, and oxidative stress. Phenotypic associations encompass abnormal mitochondrial distribution and morphology, decreased nucleolus size, increased innate thermotolerance and invasive growth, altered metal and toxin resistance, and changes in vegetative growth rate and competitive fitness.