INO80 — Saccharomyces cerevisiae S288c

Summary

YGL150C in Saccharomyces cerevisiae S288c encodes an ATP-dependent chromatin remodeler with ATP hydrolase, DNA binding, histone binding, and ATP binding activities. It is a component of the INO80 complex and is associated with the centromere complex and telomeric regions. The gene is associated with transcription pausing by RNA polymerase II, chromatin decompaction, double-strand break repair, regulation of TOR signaling, response to abiotic and thermal stimuli, phospholipid anabolism, choline transport, cell quiescence, and regulation of ribosome biogenesis. Associations with traits include oxidative stress, and phenotypes such as altered X-ray and UV resistance, abnormal chromosome maintenance, auxotrophy, decreased vegetative growth, and altered chemical resistance. Studies of related genes in other species link it to reduced virulence.