HXK2 — Saccharomyces cerevisiae S288c

Summary

YGL253W in Saccharomyces cerevisiae S288c encodes a hexokinase with N-acetylglucosamine kinase, glucokinase, fructokinase, mannokinase and glucosamine kinase activities, and binds ATP and D-glucose. It is associated with glucose breakdown, carbon catabolite repression, glucose import and metabolism, the pentose-phosphate shunt, tricarboxylic acid metabolism, oxidative phosphorylation, programmed cell death, stress response, cell size control, and externalization of phosphatidylserine. The protein localises to the cytosol, nucleus and mitochondria. Associations with traits include biomass yield, respiration rate, oxidative stress, and alkali and acid sensitivity. Phenotypic links connect the gene to increased apoptosis, altered fermentative and respiratory metabolism, decreased replicative lifespan, increased innate thermotolerance and stress resistance, and abnormal bud morphology. Studies of related genes in other species have linked the family to reduced virulence.