UBR1 — Saccharomyces cerevisiae S288c

Summary

YGR184C, also known as UBR1 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a ubiquitin ligase with zinc-binding activity. The gene is associated with ubiquitin-dependent proteolysis, particularly through the N-end rule pathway, and has been linked to diverse biological processes including spindle assembly, protein folding, homologous recombination, mitosis, sporulation, mating, nucleophagy, phosphatidylethanolamine metabolism, ergosterol anabolism, steroidogenesis, and upregulation of flocculation. It localizes to the cytoplasm, nucleus, and ubiquitin ligase complex. Associations include phosphate content, oxidative stress, and numerous phenotypes such as decreased gamma ray resistance, altered chronological lifespan, increased mutation frequency, abnormal sporulation, decreased invasive and filamentous growth, altered competitive fitness, and altered resistance to chemicals, metals, and toxins. Studies of related genes in other species link the family to RING-type E3 ubiquitin transferase activity (EC 2.3.2.27).