CRM1 — Saccharomyces cerevisiae S288c

Summary

YGR218W in Saccharomyces cerevisiae S288c encodes an exportin-1/importin-beta-like protein, also known as a CRM1 repeat-containing nuclear export receptor. It binds small GTPases and GTP, and is associated with nucleocytoplasmic transport, including mRNA transport, nuclear import and export of proteins and ribosomal subunits, tRNA nuclear import, and mitotic exit. The protein localises to the nuclear pore complex, nuclear envelope, cytoplasm, and nucleus. YGR218W is linked to oxidative stress, and its disruption is associated with decreased nuclear export, abnormal nucleolar morphology, altered actin cytoskeleton, increased filamentous and invasive growth, decreased endocytosis, reduced vegetative growth rate, altered resistance to chemicals and metals, and inviability. Studies of related genes in other species connect the family to copper concentration.