RIM101 — Saccharomyces cerevisiae S288c

Summary

YHL027W (RIM101) on chromosome VIII of Saccharomyces cerevisiae S288c encodes a C2H2-type zinc-finger protein with DNA-binding transcription activator activity that binds DNA and zinc. The gene is associated with pH regulation, response to basic pH, cell wall assembly, glucan and chitin anabolism, biofilm formation, cell adhesion, vacuolar transport, and PKC signal transduction. It has been linked to calcium sensitivity, potassium concentration, salt sensitivity, and oxidative stress. Phenotypic associations include decreased invasive growth, absent pseudohyphal growth, decreased sporulation, increased cold sensitivity, decreased acid pH resistance, altered nutrient utilization, decreased biofilm formation, decreased autophagy, increased chronological lifespan, and altered stress and metal resistance. The product localizes to both cytoplasm and nucleus. Studies of related genes in other species link the family to altered virulence.