GPA1 (YHR005C) — Saccharomyces cerevisiae S288c

Summary

YHR005C in Saccharomyces cerevisiae S288c encodes a protein with GTPase activity, guanyl nucleotide binding, and G protein-coupled receptor binding, and contains a Tim10-like domain. It is associated with the heterotrimeric G-protein complex, small TIM complex, and mitochondrial inner membrane. The gene is linked to karyogamy, nuclear movement, pheromone response, cAMP metabolism, and protein targeting. Phenotypic associations include decreased nuclear fusion during mating, absent mating response and pheromone-induced cell cycle arrest, increased heat and cold sensitivity, increased chronological lifespan, decreased sporulation efficiency, and abnormal cell shape and size. The gene is also associated with germination rate and respiratory growth defects. Studies of related genes in other species have linked the family to reduced virulence.