YOR1 — Saccharomyces cerevisiae S288c

Summary

YGR281W in Saccharomyces cerevisiae S288c encodes an ABC transporter with ATP-coupled transmembrane transporter activity, haem-transporting ATPase activity, and cadmium ion transmembrane transporter activity. It is associated with heme export from vacuole to cytoplasm, cellular detoxification of cadmium ion, PC2 import into vacuole, glutathione transport into vacuole, and xenobiotic detoxification by transmembrane export across the plasma membrane. The gene is linked to vacuolar membrane and fungal-type vacuole membrane localisation, as well as extracellular vesicle and plasma membrane locations. Associations include response to metal, response to toxic substance, tryptophan transport, and homotypic vacuole fusion. Phenotypic connections involve increased exponential growth rate, altered telomere length, decreased chronological lifespan, abnormal chemical compound accumulation, and altered resistance to chemicals. Studies of related genes in other species link the family to similar detoxification and transport functions.