HIP1 — Saccharomyces cerevisiae S288c

Summary

YGR191W, also known as GAP1 or HIP1, encodes an amino acid permease in Saccharomyces cerevisiae S288c, a transmembrane transporter with activity for L-proline, L-arginine, L-lysine, and other amino acids. The gene is associated with the transport of histidine, tyrosine, lysine, phenylalanine, glutamine, leucine, and S-adenosylmethionine, as well as with proline breakdown, sphingolipid anabolism, regulation of amino acid transport and arginine metabolism, and downregulation of endocytosis. It has been linked to traits including nitrogen content, potassium uptake, and acid sensitivity, and to phenotypes such as decreased nutrient uptake, increased cold sensitivity, altered vegetative growth, and changes in chemical compound accumulation and resistance. The protein localizes to the plasma membrane, Golgi membrane, cell tip, and extracellular vesicles. Studies of related genes in other species, including GAP2 and GAP6, connect the family to similar transport functions.