CLB1 — Saccharomyces cerevisiae S288c

Summary

YGR108W in Saccharomyces cerevisiae S288c encodes a cyclin, a member of the cyclin-box domain family, with cyclin-dependent protein serine/threonine kinase activator activity and regulator activity, and protein kinase activity. This gene is associated with regulation of exit from meiosis, spindle assembly checkpoint, regulation of spore germination, mitotic exit, metaphase, meiotic M phase, spindle assembly, embryonic cleavage, nuclear division, import into cell, mitotic cell cycle phase transition, regulation of morphogenesis, negative regulation of ascospore formation, maintenance of sister chromatid cohesion, regulation of G1/S transition of mitotic cell cycle, spindle localization, mitotic anaphase A, and protein modification. The encoded protein localizes to the CDK holoenzyme, MTOC, new and old SPB, meiotic and mitotic spindles, nucleoplasm, and other sites. Associations with protein content and decreased chronological lifespan have been noted. Studies of related genes in other species link the family to similar cell cycle regulatory roles.