SPT6 — Saccharomyces cerevisiae S288c

Summary

YGR116W (SPT6) on chromosome VII of Saccharomyces cerevisiae S288c encodes a protein with DNA-binding transcription antitermination factor activity, nucleosome-binding and histone-binding activities. The protein contains Spt6-specific domains including HTH, SH2 and acidic N-terminal regions, and belongs to the TF_Spt6 family. SPT6 is associated with transcriptional readthrough, RNA elongation from Pol II promoters, mRNA processing, lncRNA transcription, co-transcriptional chromatin reassembly, nucleosome organization, ribosome biogenesis, DNA replication, and the G1/S transition of the mitotic cell cycle. It localizes to the transcription elongation factor complex and euchromatin. Phenotypic associations include decreased chromosome segregation, delayed S-phase progression, increased mitotic recombination, decreased filamentous and invasive growth, increased heat sensitivity, decreased toxin and metal resistance, and altered competitive fitness. Studies of related genes in other species link the family to unaffected pathogenicity.