DAM1 — Saccharomyces cerevisiae S288c

Summary

YGR113W in Saccharomyces cerevisiae S288c encodes a microtubule plus-end binding protein that is a component of the DASH/Dam1 complex. The gene is associated with mitotic spindle organization, sister chromatid cohesion, chromosome biorientation, centromere clustering, and spindle checkpoint function. It is linked to protein localization to the centromere, upregulation of microtubule polymerization, and asymmetric cell division. The protein localizes to the mitotic spindle polar microtubule, the DDD complex, the mitotic spindle pole body, and the cytoplasm. Deletion of YGR113W is associated with inviability, delayed cell cycle progression, abnormal spindle and nucleolar morphology, decreased oxidative stress resistance, reduced vegetative growth and competitive fitness, and altered chemical resistance. The gene is also connected to the related gene DAM1.