HAP2 — Saccharomyces cerevisiae S288c

Summary

YGL237C (HAP2) on chromosome VII of Saccharomyces cerevisiae S288c encodes a CCAAT-binding factor subunit (NFYA family) and is annotated as a DNA-binding transcription activator specific for RNA polymerase II with promoter-enhancer loop anchoring activity. The gene is associated with numerous biological processes including cytochrome and heme anabolism, aerobic respiration regulation, oxidative phosphorylation, mitochondrial biogenesis, glucose import, TCA cycle, glyoxylate metabolism, isoprenoid anabolism, and responses to salinity, anoxia, nitrosative stress, and yeast. It is linked to traits such as biomass yield, oxidative stress, and salt tolerance, and to phenotypes including decreased cell size, sporulation efficiency, respiratory growth, UV resistance, desiccation resistance, and competitive fitness, as well as increased protein secretion, chemical compound excretion, and oxidative stress resistance. The protein localizes to the nucleus and heterochromatin. Studies of related genes in other species place the family in the CCAAT-binding factor complex.