SAE2 — Saccharomyces cerevisiae S288c

Summary

YGL175C in Saccharomyces cerevisiae S288c encodes a protein containing a Ctp1_C domain. The gene is associated with a broad range of DNA repair and genome maintenance processes, including double-strand break repair via non-homologous end joining and homologous recombination, base excision repair, postreplication repair, and the DNA damage checkpoint. It is also linked to meiotic cell cycle progression, telomere maintenance, sister chromatid cohesion, and R-loop processing. Phenotypically, loss of YGL175C function is associated with decreased resistance to X-rays, gamma rays, UV, and oxidative stress, increased mutation frequency and transposable element transposition, altered mitotic recombination, defective sporulation, reduced vegetative growth rate, and decreased competitive fitness. The gene is further connected to response to the DNA-damaging agent MMS and to bleomycin.