MAD1 — Saccharomyces cerevisiae S288c

Summary

YGL086W in Saccharomyces cerevisiae S288c encodes the Mad1 protein, a kinetochore adaptor associated with the spindle assembly checkpoint. The gene is associated with mitotic and meiotic chromosome segregation, spindle elongation, sister chromatid cohesion, and the activation and negative regulation of the spindle assembly checkpoint. It localises to the kinetochore, mitotic spindle, nuclear envelope, and spindle pole body. YGL086W has been linked to numerous phenotypes including decreased vegetative growth, reduced spore germination, abnormal chromosome maintenance, increased heat sensitivity, altered competitive fitness, decreased chronological lifespan, and changes in resistance to chemicals and toxins. It is also connected to oxidative stress, decreased apoptosis, and altered cell cycle progression in G1 phase. Studies of related genes in other species link the family to further cell cycle functions.