MLC1 — Saccharomyces cerevisiae S288c

Summary

YGL106W, also known as MLC1, encodes a myosin light chain protein in Saccharomyces cerevisiae S288c on chromosome VII. The product contains EF-hand domains and is annotated for calcium ion binding. MLC1 is associated with cytokinesis, as its deletion leads to absent or abnormal cell division, and it localizes to the myosin II complex, the mitotic actomyosin contractile ring, and the cell division site. The gene is also linked to mitochondrion distribution, morphogenesis, and protein breakdown. Phenotypic associations include inviability, haploid insufficiency, and increased chemical resistance. Studies of related genes in other species connect the family to germination rate and loss of pathogenicity.