HSF1 — Saccharomyces cerevisiae S288c

Summary

YGL073W (HSF1) on chromosome VII of Saccharomyces cerevisiae encodes a heat shock transcription factor with RNA polymerase II-specific DNA-binding transcription activator activity, sequence-specific DNA binding, identical protein binding, and phosphorelay response regulator activity. The protein localises to the nucleus, cytoplasm, chromatin, and DNA-protein complexes. HSF1 is associated with responses to heat, stress, superoxide, singlet oxygen, and hypotonic conditions, as well as ER stress response, TOR signaling, innate immunity, spindle pole body assembly, and DHN-melanin biosynthesis. The gene is linked to traits including drought tolerance, oxidative stress, and quantum yield. Phenotypic associations include altered thermotolerance, heat sensitivity, cell cycle progression, vegetative growth, budding index, spindle morphology, invasive growth, UV and metal resistance, competitive fitness, and chromosome maintenance. Studies of related genes in other species link the family to reduced virulence.