PDR1 — Saccharomyces cerevisiae S288c

Summary

YGL013C (AMY1) in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription activator with RNA polymerase II-specific activity, containing a Zn2-C6 fungal-type DNA-binding domain. It is associated with diverse biological processes including bypass DNA synthesis, positive regulation of cellular response to drug, intracellular receptor signaling, alkane transport, UTP breakdown, cellular detoxification, the pentose-phosphate shunt, response to progesterone, nucleotide excision repair, lipid homeostasis, lipid A metabolism, IL-2 production, oxidative phosphorylation, response to fungi, amino acid anabolism, cellular response to xenobiotic stimulus, and homologous recombination. The gene product localizes to the nucleus, cytosol, and fungal biofilm matrix. Phenotypic associations include altered RNA accumulation, decreased vegetative growth and growth rate, abnormal vacuolar morphology, altered competitive fitness, and both increased and decreased resistance to chemicals. Related genes in other species are linked to increased virulence.