YPT1 — Saccharomyces cerevisiae S288c

Summary

YFL038C (YPT1) encodes a Rab-family small GTPase with GTPase activity and GTP binding. In Saccharomyces cerevisiae, Ypt1 is associated with cisternal maturation, ER-phagy and its regulation, the ERAD pathway, vesicle docking at the Golgi, macroautophagy, vesicle uncoating, and membrane addition at sites of cytokinesis. It localises to transport vesicle membranes, the recycling endosome, the endomembrane system, and the pre-autophagosomal structure. The gene is linked to cell cycle progression, nutrient uptake, protein secretion, autophagy, reticulophagy, sporulation, growth rate, cold and heat sensitivity, starvation resistance, toxin resistance, and vegetative growth. Associations with oxidative stress and abnormal redox state, cytoskeleton, endomembrane system, and nuclear morphology have also been noted. Studies of related genes in other species connect the family to membrane traffic regulation.