ECO1 — Saccharomyces cerevisiae S288c

Summary

YFR027W encodes a protein with peptide-lysine-N-acetylase activity, DNA-directed DNA polymerase activity, damaged DNA binding, chromatin binding, and zinc binding. The gene is associated with sister chromatid cohesion, chromosome condensation, spindle assembly checkpoint, response to oxidative stress, telomere organization, and chromatin looping. It localizes to the replication fork, nuclear replication fork, sites of double-strand breaks, chromatin, and the nucleus. The gene is linked to decreased X-ray and gamma-ray resistance, abnormal chromosome segregation, decreased spore germination, abnormal spindle morphology, decreased mitotic recombination, increased heat sensitivity, and decreased oxidative stress resistance. Related genes in other species connect the family to acetyltransferase activity.