ACT1 — Saccharomyces cerevisiae S288c

Summary

YFL039C (ACT1) on chromosome VI of Saccharomyces cerevisiae S288c encodes a structural constituent of the cytoskeleton with ATP hydrolase activity and identical protein binding. The gene is associated with actin cytoskeleton organization, polymerization, depolymerization, and filament stabilization, as well as vacuole fusion, cytoplasmic streaming, autophagic cell death, and DNA damage checkpoint. It localizes to actin filament bundles, the actin cytoskeleton, and the fungal biofilm matrix. Phenotypic associations include abnormal actin cytoskeleton morphology, increased cold sensitivity, decreased endocytosis, increased invasive growth, abnormal cell cycle progression, and absent respiratory growth. The gene is also linked to sugar content, salt sensitivity, and oxidative stress. Studies of related genes in other species connect the family to reduced virulence.