TUB2 — Saccharomyces cerevisiae S288c

Summary

YFL037W (TUB2) on chromosome VI of Saccharomyces cerevisiae S288c encodes a protein with beta-tubulin and tubulin domains, and is annotated as a structural constituent of the cytoskeleton with GTPase activity and GTP binding. The product localises to microtubules, the tubulin complex, and spindle and cytoplasmic microtubules. TUB2 is associated with microtubule-based processes including spindle assembly and elongation, nuclear migration, microtubule dynamics, and cell cycle control from G1 phase through mitotic prophase and anaphase. It is also linked to locomotion, intracellular transport, protein arginylation, and positive regulation of intracellular protein transport. Phenotypic associations connect the gene to abnormal spindle and nuclear morphology, cell cycle arrest or delay, altered cold, heat, UV and metal sensitivity, decreased vegetative growth and competitive fitness, and changes in telomere length and chemical resistance. Studies of related genes in other species link the family to chemical resistance.