STE2 — Saccharomyces cerevisiae S288c

Summary

YFL026W in Saccharomyces cerevisiae S288c encodes a protein with P-factor receptor activity and mating-type factor pheromone receptor activity. This gene is associated with detection of pheromone, pheromone response, pheromone processing, positive regulation of pheromone response MAPK cascade, adenylyl cyclase activation, cell-cell fusion, chemotropism, and mating behavior. It is linked to phenotypes including absent pheromone sensitivity, absent or decreased mating response, decreased mating efficiency, decreased cell fusion, and altered shmoo formation. The protein localizes to the plasma membrane, mating projection membrane, cell tip, cell cortex, and fungal-type vacuole. Related genes in other species link the family to pheromone sensing and mating processes.