DMC1 — Saccharomyces cerevisiae S288c

Summary

YER179W, also known as DLH1 or DMC1, encodes a recombinase with ATP hydrolase activity that binds single- and double-stranded DNA and interacts with the Sae3-Mei5 complex. This gene is associated with meiotic chromosome segregation, meiotic strand invasion involved in reciprocal meiotic recombination, double-strand break repair during meiotic recombination, and the pachytene and DNA damage checkpoints. It localizes to the nucleus, chromatin, condensed nuclear chromosomes, centromere complexes, and sites of double-strand breaks. Phenotypic associations include abnormal, increased, or decreased meiotic recombination, abnormal meiosis, decreased sporulation and spore germination, decreased anaerobic growth, reduced carbon source utilization, decreased starvation resistance, abnormal chemical compound accumulation, abnormal vacuolar morphology, and decreased competitive fitness. Studies of related genes in other species link the family to meiotic recombination.