TOG1 — Saccharomyces cerevisiae S288c

Summary

YER184C in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription activator specific to RNA polymerase II, belonging to the Zn2-C6 fungal-type DNA-binding domain family. The gene is associated with NADPH regeneration, fatty acid oxidation, gluconeogenesis, alkane transport, and cellular responses to xenobiotic and drug stimuli. It has been linked to oxidative stress, salt tolerance, and multiple phenotypes including decreased respiratory metabolism and growth, increased heat sensitivity and invasive growth, altered chemical resistance, and abnormal peroxisomal morphology. The product localizes to the nucleus, cytosol, and fungal biofilm matrix. Studies of related genes in other species connect this gene family to hypervirulence.