CHD1 — Saccharomyces cerevisiae S288c

Summary

YER164W (CHD1) on Saccharomyces cerevisiae chromosome V encodes a protein with ATP-dependent chromatin remodeler activity, DNA translocase activity, helicase activity, histone carrier activity, and nucleosome binding, and it contains chromodomain and SNF2-like domains. The gene is associated with chromatin organization, homologous recombination, DNA damage checkpoint, sister chromatid cohesion, MAPK cascade, and ribosome biogenesis. It localizes to heterochromatin, the SHREC and SWI-SNF complexes, and CENP-A-containing chromatin. Phenotypically, CHD1 is linked to decreased osmotic stress resistance, increased stress resistance and chronological lifespan, altered vegetative growth, and absent filamentous and invasive growth. Studies of related genes in other species connect the family to DNA translocase activity (EC 3.6.4.12).