TSC11 — Saccharomyces cerevisiae S288c

Summary

YER093C in Saccharomyces cerevisiae S288c encodes a protein that belongs to the RICTOR_M, Rictor_IV, RICTOR_V, Pianissimo_fam, and Pianissimo_N domain families, and contains HR1 and ARM-type repeats. The gene is associated with TORC2 signaling, TOR signaling, regulation of kinase activity, cell growth, response to chemical, SAPK signaling, JNK cascade, chemotaxis, and regulation of filamentous growth. It is linked to membrane, cell cortex, cell division site, mitochondria, cytoplasm, cytosol, and nucleus localisation. Associations include oxidative stress, acid sensitivity, and numerous phenotypes such as decreased biofilm formation, decreased competitive fitness, increased oxidative stress resistance, increased replicative lifespan, decreased chronological lifespan, increased heat sensitivity, decreased vegetative growth rate, and abnormal mitochondrial genome maintenance, actin cytoskeleton morphology, and nucleolus size.