UBP9 — Saccharomyces cerevisiae S288c

Summary

YER098W in Saccharomyces cerevisiae S288c encodes a metal-dependent deubiquitinase with thiol-dependent deubiquitinase activity, belonging to the peptidase C19 (ubiquitin-specific protease) family. The gene is associated with lytic switch, viral transcription and transformation, NF-kappaB activation, regulation of IL-2 production, T cell activation, protein kinase A activation, activation of CREB, response to virus, cAMP, hypoxia, and nerve growth factor, as well as carbon catabolite repression of transcription, organogenesis, cell fate determination, protein acetylation, and regulation of binding. The product localises to the cell tip, cell division site, cytosol, and nucleus. Phenotypic associations include altered protein activity and accumulation, changes in UV resistance, competitive fitness, vegetative growth rate, chemical resistance, and haploinsufficiency. Studies of related genes in other species link the family to ubiquitin-specific protease activity (EC 3.4.19.12).