RNR1 — Saccharomyces cerevisiae S288c

Summary

YER070W (RNR1) on chromosome V of Saccharomyces cerevisiae encodes the large subunit of ribonucleoside-diphosphate reductase, an enzyme with ribonucleoside-diphosphate reductase activity (thioredoxin disulfide as acceptor) and ATP binding. The gene is associated with deoxyribonucleotide anabolism, DNA damage response, homologous recombination, telomere maintenance, TOR signaling, mitochondrial biogenesis, and cell cycle modulation. The RNR1 product localises to the RNR complex, cytoplasm, and cytosol. Associations with traits include potassium concentration, oxidative stress, and acid sensitivity. Phenotypic links connect RNR1 to increased UV resistance, altered telomere length, decreased replicative and chronological lifespan, increased cell size, abnormal bud morphology, decreased biofilm formation, and reduced resistance to oxidative stress, heat, hyperosmotic stress, and desiccation. The family also contains the enzyme class 1.17.4.1 based on sequence similarity to related genes in other species.