PXP1 — Saccharomyces cerevisiae S288c

Summary

YEL020C (PXP1) in Saccharomyces cerevisiae S288c on chromosome V encodes a protein with 2-hydroxyacyl-CoA lyase activity, also annotated with acetolactate synthase and pyruvate decarboxylase activities, and binds TPP, magnesium, and FAD. The protein localises to the peroxisomal lumen, mitochondria, cytosol, and nucleus. PXP1 is associated with fatty acid alpha-oxidation, the ER-nuclear signalling pathway, regulation of the ER stress response, response to misfolded protein, ER stress-induced apoptosis, translational attenuation, and fumarate metabolism. It is also linked to oxidative stress and traits including increased mitotic recombination, decreased respiratory growth, decreased sporulation efficiency, increased replicative lifespan, decreased competitive fitness, and decreased resistance to chemicals. Studies of related genes in other species link the family to loss of pathogenicity.