RAD23 — Saccharomyces cerevisiae S288c

Summary

YEL037C (RAD23) on chromosome V of Saccharomyces cerevisiae S288c encodes a protein that binds damaged DNA, ubiquitin, polyubiquitin-modified proteins, and the proteasome, and contains UBA and ubiquitin-like domains. The gene is associated with nucleotide excision repair, postreplication repair, homologous recombination, the DNA damage response, and regulation of protein breakdown. It is linked to gluconeogenesis, photomorphogenesis, protein deglycosylation, heme A biosynthesis, and cell-cycle processes including metaphase, anaphase, and spindle assembly. The protein localizes to the nucleus, nucleoplasm, nuclear envelope, and cytosol. Associations with traits include male sterility, salt sensitivity, and oxidative stress. Phenotypic connections encompass decreased UV resistance, reduced replicative lifespan, altered sporulation efficiency, decreased acid pH and desiccation resistance, increased toxin resistance, and abnormal chromosome maintenance.