MIG3 — Saccharomyces cerevisiae S288c

Summary

YER028C, also known as MIG1 or MIG3, encodes a C2H2-type zinc-finger DNA-binding transcription repressor specific to RNA polymerase II in Saccharomyces cerevisiae S288c. The protein localises to the nucleus, nucleoplasm, cytoplasm and cytosol. It is associated with the downregulation of transcription from RNA polymerase II promoters by glucose, regulation of carbon utilisation, and responses to methanol and chemical stimuli. The gene has been linked to cell cycle modulation, invasive growth, pexophagy, pheromone response, and the upregulation of the ER stress response. Associations with traits include carotenoid and carbohydrate content, biomass yield, protein content, calcium sensitivity, and oxidative stress. Phenotypic links include decreased chronological lifespan, altered cell cycle progression, reduced UV and oxidative stress resistance, increased heat sensitivity, and decreased competitive fitness.