PRE1 — Saccharomyces cerevisiae S288c

Summary

YER012W (PRE1) on chromosome V of Saccharomyces cerevisiae S288c encodes a beta-type subunit of the proteasome core complex, possessing threonine endopeptidase activity and endopeptidase activator activity. The gene is associated with proteasomal protein catabolic processes, including ubiquitin-independent protein breakdown, as well as antigen processing, APP catabolism, and proteolysis. PRE1 has been linked to ergosterol anabolism, maltose transport, proline and glutamate metabolism, and responses to starvation, alcohol, and pheromone detection. Localization evidence places the product in the proteasome core complex, cytoplasm, nucleus, nuclear envelope, and ER membrane. Phenotypic associations include abnormal cytokinesis, cell cycle progression, sporulation absence, increased heat sensitivity, altered chemical resistance, reduced vegetative growth and competitive fitness, and inviability. Studies of related genes in other species connect the family to threonine-type endopeptidase activity (EC 3.4.25.1).