URA3 — Saccharomyces cerevisiae S288c

Summary

YEL021W in Saccharomyces cerevisiae S288c encodes a protein with orotidine-5'-phosphate decarboxylase and orotate phosphoribosyltransferase activities. The gene is associated with uracil metabolism, UMP anabolism, and purine nucleotide metabolism, as well as processes including pyrimidine dimer repair, regulation of flocculation, and autotrophy. It has been connected to traits such as sugar content, nickel content, acid sensitivity, and oxidative stress, and to phenotypes including decreased ionic stress resistance, auxotrophy, increased heat sensitivity, and altered chemical resistance. The product localises to the cytosol. Studies of related genes in other species link the family to salt tolerance.