XRS2 — Saccharomyces cerevisiae S288c

Summary

YDR369C encodes a protein containing a forkhead-associated (FHA) domain, a phosphopeptide-binding module characteristic of the SMAD_FHA domain superfamily. The gene is associated with numerous DNA repair and genome maintenance processes, including homologous recombination, non-homologous end joining, base excision repair, nucleotide excision repair, postreplication repair, and bypass DNA synthesis. It is also linked to mtDNA replication, telomere maintenance, the DNA damage checkpoint, and sumoylation. Phenotypically, YDR369C is associated with decreased resistance to gamma rays, UV, oxidative stress, heat, and desiccation, as well as increased mutation frequency and transposable element transposition. Additional associations include decreased sporulation, fermentative growth rate, and competitive fitness, alongside abnormal vacuolar and endoplasmic reticulum morphology. The gene is further connected to potassium concentration and oxidative stress traits.