CNL1 — Saccharomyces cerevisiae S288c

Summary

YDR357C, also known as CLN1 or CNL1 on chromosome IV of Saccharomyces cerevisiae S288c, encodes a protein of the CNL1 family. The gene is associated with a wide range of biological processes, including embryonic cleavage, response to peptide, regulation of kinase activity, cell cycle transition, septin checkpoint, regulation of DNA replication, and spindle pole body assembly. It has also been linked to glucose breakdown, glycogen metabolism, acetyl-CoA and ceramide anabolism, NO storage, endosome organization, regulation of cell morphogenesis and protein localization, cell activation, and response to UV-A. The protein localizes to the cytoplasm, endosome, and BLOC-1 complex. Phenotypic associations include altered replicative lifespan, increased oxidative stress resistance, changes in competitive fitness, abnormal vacuolar morphology, and varied chemical resistance.