DIN7 — Saccharomyces cerevisiae S288c

Summary

YDR263C, also known as EXO1 in Saccharomyces cerevisiae S288c, encodes a protein with 5'-3' DNA exonuclease activity, 5' flap endonuclease activity, and dsDNA binding, and is annotated with XPG/Rad2 family domains. This gene is associated with base excision repair, nucleotide excision repair, mismatch repair, ribonucleotide excision repair, meiotic DNA double-strand break processing, Okazaki initiator RNA removal, telomere organization and assembly, maintenance of DNA trinucleotide repeats, and sister chromatid cohesion. The protein localizes to the nucleus, nucleolus, nucleoplasm, site of double-strand breaks, and mitochondria. YDR263C is associated with decreased oxidative stress resistance, abnormal chemical compound accumulation, and altered resistance to chemicals, as well as phosphate content and oxidative stress traits. Related genes in other species link the family to similar DNA repair functions.